Disabling dyspnea at rest or with minimal exertion and little or
no response to bronchodilators, resulting in decreased functional capacity,
fatigue and cough and
Progression of end stage pulmonary disease, as evidenced by prior
increasing visits to the emergency department or prior hospitalizations
for pulmonary infections and/or respiratory failure and
Room air findings of hypoxemia, as evidenced by pO2 < 55 mmHg
and oxygen saturation < 88% or hypercapnia, as evidenced by pCO2 > 50
mmHg
Cor pulmonale and right heart failure (RHF) secondary to pulmonary
disease (e.g., not secondary to left heart disease or valvulopathy)
Unintentional progressive weight loss greater than 10% of body weight
over the preceding six months
